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Post Doctoral Training Fellows


Closing Date 27/09/2020, 23:55

Location London

Division Radiotherapy and Imaging

Team Targeted Therapy

Vacancy Type Full time

Type of Contract Fixed Term

Length of Contract 3 years contract

Hours per Week 35

Salary Range £32,200 - £38,600

The Institute of Cancer Research, London, is one of the world's most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. We provided the first convincing evidence that DNA damage is the basic cause of cancer, laying the foundation for the now universally accepted idea that cancer is a genetic disease. Today, The Institute of Cancer Research (ICR) leads the world at isolating cancer-related genes and discovering new targeted drugs for personalised cancer treatment.

Under the leadership of our Chief Executive, Professor Paul Workman FRS, the ICR is ranked as the UK's leading academic research centre. Together with our partner The Royal Marsden, we are rated in the top five cancer centres globally.

The ICR is committed to attracting, developing and retaining the best minds in the world to join us in our mission - to make the discoveries that defeat cancer. Following the recent award of a CRUK-funded Radiation Research Centre of Excellence at The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, we are establishing a critical mass of new radiation-focused research that will build on our strengths in basic, translational and clinical research. We will seek to improve outcomes for cancer patients by understanding and modulating fundamental biological processes that occur in irradiated tumour and normal cells to investigate the potential to exploit radiation-induced DNA damage and cell death processes to drive effective anti-tumour immune responses with minimal normal tissue damage. The central goal of this initiative will be to link discovery, translational and clinical research with direct line of sight to patient benefit.

We are committed to training the next generation of radiation researchers through a connected programme of complementary preclinical and clinical research themes. In order to achieve this, we are now seeking to recruit 4 postdoctoral training fellows to work on biology research projects that span the main research themes within our CRUK Radiation Research Centre of Excellence. All posts are designed to drive collaborative research initiatives across more than one research group with the following key areas of interest:

Molecular responses to radiation-induced DNA damage

This research will be coordinated by Professor Jonathon Pines, FRS, an expert on the regulation of the cell cycle and mitosis. Research projects will be led by Professors Jessica Downs and Wojciech Niedzwiedz, both world-leaders in the DNA damage response, with specific expertise in chromatin biology and replication-coupled DNA repair, respectively.

Harnessing cell death mechanisms to modulate RT-induced immune responses

This work will be co-ordinated by Professor Pascal Meier who is pre-eminent in the field of cell death and inflammation. Research projects will also be led by Professor Jyoti Choudhary who leads the Functional Proteomics laboratory and has developed methodologies to interrogate the proteome and immunopeptidome of cancer cells.

Radiation-induced innate and adaptive immune responses

This area will be led by Professors Kevin Harrington and Alan Melcher, both of whom have expertise in the fields of combining radiation with biological agents and/or novel radiosensitisers, and will draw on existing laboratory expertise in immune readouts that will be applicable to preclinical and clinical samples across all research themes.

All research projects will seek to bring together expertise across different teams, including a number of new radiation-focused group leader posts, and will link to a team of radiation oncologists with unparalleled expertise in conducting clinical trials of radiotherapy that will be leveraged as part of the forward and reverse translational activities of our Centre of Excellence. This link between basic, translational and clinical research will ensure that our Centre delivers better outcomes for patients receiving radiotherapy.

For any informal queries regarding the postdoctoral positions and projects available, please contact: Professor Kevin Harrington ([email protected])

We consider all applications on merit and have a strong commitment to enhancing the diversity of our staff.

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London, England, London, EC2V, United Kingdom

  • Ad ID:  15910458
  • Ad Type:  Offered
  • Posted on:  29/09/2020, 03:09
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